



Dihydroberberine
CAS No.: 483-15-8
MOQ: 200KG
Dihydroberberine (HPLC) is a hydrogenated derivative of berberine, a bioactive alkaloid found in plants like Berberis vulgaris (barberry), Coptis chinensis, and Hydrastis canadensis (goldenseal). It is formed by reducing berberine’s double bonds, which enhances its bioavailability and metabolic stability.
Chempora is a leading supplier of Dihydroberberine (DHB) , we provide customers with high quality Dihydroberberine, if you have any requirements, please feel free to contact [email protected], we will reply you as soon as possible.
Specification Available: USP
Product Introduction of Dihydroberberine
Dihydroberberine (DHB) is a hydrogenated derivative of berberine, a bioactive alkaloid found in plants like goldenseal, barberry, and Chinese goldthread. It is known for its potential enhanced bioavailability compared to regular berberine, which is poorly absorbed in the gut.

Dihydroberberine Basic Information
- Chemical Formula: C20H19NO4
- Chemical Name: 5,6-Dihydroberberine
- Molecular Weight: 337.37 g/mol 2
- Purity: 98%
- Appearance: light yellow to white crystalline powder
- Solubility: slightly soluble in water, easily soluble in organic solvents (such as DMSO, ethanol)
- Stability: avoid light and moisture, it is recommended to store in a cool and dry place (2-8°C is best)
Key Benefits of Dihydroberberine
1. Blood Sugar Regulation
Dihydroberberine has been shown to effectively improve insulin sensitivity, support healthy blood sugar levels, and enhance glucose metabolism. It is considered more potent than berberine in its ability to manage blood sugar, making it a promising supplement for individuals with insulin resistance or type 2 diabetes.
2. Enhanced Fat Metabolism
This compound has demonstrated the ability to modulate lipid metabolism, which may help in reducing body fat and managing cholesterol levels, contributing to better heart health and weight management.
3. Anti-Inflammatory and Antioxidant Effects
Dihydroberberine provides strong anti-inflammatory benefits, which can help reduce chronic inflammation associated with various metabolic disorders. Additionally, its antioxidant properties aid in neutralizing harmful free radicals, supporting overall cellular health and slowing the aging process.
4. Improved Bioavailability
Compared to regular berberine, Dihydroberberine offers enhanced absorption and longer-lasting effects, making it a more effective choice for therapeutic purposes.
Product Parameter of Dihydroberberine
Items | Specifications | Test Results | Methods |
---|---|---|---|
Specifications | |||
Purity of Dihydroberberine | NLT 98.0 % | 99.30 % | HPLC |
Assay of Dihydroberberine | NLT 98.0 % | 99.52% | HPLC |
Physical & Chemical Control: | |||
Appearance | Yellow powder | Conforms | Organoleptic |
Odor & Taste | Characteristic | Conforms | Organoleptic |
Identification | HPLC retention time correspond to Reference Standard | Conforms | In house HPLC |
Particle size | NLT 90% pass 40 mesh | Conforms | USP <786> |
Water | NMT 1.0 % | 0.19% | USP <921> |
Residue on ignition | NMT 1.0 % | 0.05 % | USP <281> |
Bulk density (loose) | NLT 0.5 g/ml | 0.63 g/ml | USP <616> |
Bulk density (tapped) | NLT 0.7 g/ml | 0.84 g/ml | USP <616> |
Residual solvents | Under USP <467> limits | Conforms | USP <467> |
Residual pesticides | Under USP <565> limits | Conforms | USP <565> |
Heavy Metals Control: | |||
Heavy Metals | NMT 10 mg/kg | Conforms | USP <233> |
Lead | NMT 2.0 mg/kg | 0.152 mg/kg | USP <233> |
Arsenic | NMT 2.0 mg/kg | 0.018 mg/kg | USP <233> |
Cadmium | NMT 1.0 mg/kg | ND | USP <233> |
Mercury | NMT 1.0 mg/kg | ND | USP <233> |
Microbiological Control: | |||
Total Plate Count | NMT 1,000 cfu/g | <10 cfu/g | USP <61> |
Yeast & Mold | NMT 100 cfu/g | <10 cfu/g | USP <61> |
E. Coli | Negative | Conforms | USP <62> |
Salmonella | Negative | Conforms | USP <62> |
S. Aureus | Negative | Conforms | USP <62> |
Packing: Pack in fiber-drums double and plastic-bags inside. Net weight 20kg/drum. | |||
Storage: Sealed and stored in cool and dry place, protect from direct sunlight and moisture. |
Why choose to buy Chempora of Dihydroberberine?
Chempora is a trusted trading company specializing in high-quality ingredients and raw materials for various industries, including nutritional supplements, food additives, feed additives, and herbal extracts. They focus on providing top-notch products, reliable supply chains, and professional support, which makes them a reliable partner for businesses worldwide.
When choosing to buy Chempora’s Dihydroberberine, you can expect:
1. High Quality : They offer Dihydroberberine that meets stringent quality control standards.
2. Reliable Supply Chain: Ensuring timely deliveries and consistent product availability.
3. Competitive Pricing: Offering competitive rates without compromising quality.
4. Professional Support: Expert advice and tailored solutions to meet specific customer needs.
This makes Chempora a solid choice if you’re looking for high purity and dependable Dihydroberberine products.
Contact Us
CHEMPORA CO., LIMITED
Contact Person: Mr. Stephen Ding
Tel:0086-21-58930128
WhatsApp & Wechat: +8615026665594
E-mail: [email protected]
Application of Dihydroberberine
Dihydroberberine (HPLC) can be used in a variety of products, primarily in health and wellness sectors:
1. Dietary Supplements
Dihydroberberine is commonly used in supplements for blood sugar management, weight loss, heart health, and general metabolic support due to its effects on glucose regulation and fat metabolism.
2. Functional Foods
It can be added to low-sugar or low-carb foods to help manage blood sugar levels and promote fat burning.
3. Skincare Products
Dihydroberberine’s antioxidant and anti-inflammatory properties make it useful in anti-aging and skin-soothing formulations.
4. Sports Nutrition
Dihydroberberine is found in supplements that support fat burning, energy metabolism, and improved athletic performance.
5. Metabolic Support Products
Used in products designed to support overall metabolic health, especially for managing conditions like metabolic syndrome.






Berberine HCl Powder holds significant application value across multiple industries. Its natural, effective, and multifunctional properties make it an ideal raw material for use in food, pharmaceuticals, healthcare, and scientific research fields. For more information, please feel free to contact us !
Differences between Dihydroberberine and Berberine HCL Powder
Dihydroberberine and Berberine HCL Powder are both derived from the same plant family, but they have distinct differences in terms of their chemical structure, bioavailability, and potential health benefits. Here’s a breakdown of the key differences:
Property | Dihydroberberine (DHB) | Berberine HCL Powder |
---|---|---|
Bioavailability | Higher bioavailability, absorbed more efficiently in the body | Lower bioavailability, requires higher doses for similar effects |
Effectiveness | More potent in lowering blood glucose and improving insulin sensitivity | Effective, but generally less potent than DHB in comparison |
Metabolism | Faster and more easily metabolized due to better absorption | Slower metabolism with potential for more gastrointestinal discomfort |
Side Effects | Fewer gastrointestinal side effects due to better absorption | May cause digestive issues like nausea or upset stomach |
Applications | Used in dietary supplements for better blood sugar control, fat loss, and cardiovascular health | Widely used for managing blood sugar, cholesterol, and metabolic health |
Cost | More expensive due to enhanced bioavailability and production process | Generally less expensive, but requires higher dosage for similar benefits |
More Product Recommendations
Chempora is a professional supplier of food additives , nutritional supplements , feed additives. In addition to Dihydroberberine, we can also provide you with other product. We look forward to your message.