N-ACETYL-L-CYSTEINE
N – Acetyl – L – Cysteine (NAC) is an acetylated derivative of L – Cysteine and is a key precursor for synthesizing glutathione. It has strong antioxidant properties, can dissolve mucus, and assists in detoxification. It is widely used in respiratory care, liver protection, dietary supplementation, and clinical detoxification, and is a commonly used component in the pharmaceutical and health care fields.
Chempora is a leading supplier of N – Acetyl – L – Cysteine we provide customers with high quality N – Acetyl – L – Cysteine, if you have any requirements, please feel free to contact info@chempora.com, we will reply you as soon as possible.
CAS No.: 616‑91‑1
Specification Available: FCC
MOQ: 25KGs
Product Introduction of N-ACETYL-L-CYSTEINE
N-acetyl-L-cysteine (NAC) is an acetylated derivative of cysteine and is an important sulfur-containing amino acid. It is the precursor of glutathione in the body and has strong antioxidant properties, the ability to eliminate free radicals, and the function of protecting cells. It can also thin mucus, improve respiratory tract patency, assist liver metabolism, and alleviate oxidative damage. It is widely used in the fields of medicine, dietary supplements, and functional foods, and is commonly used for antioxidant, respiratory health, liver care, and daily health care. It has high safety and mature application.
Basic Information
Appearance:
A white crystalline powder
Colour:
White crystalline
Specifications of N-ACETYL-L-CYSTEINE
| ITEMS | Result |
|---|---|
| Appearance | A white crystalline powder |
| Colour | White crystalline |
| Odour | Slight acetic acid odor |
| pH value | 2 - 2.75 |
| Assay | Min 99.0% |
| Solubility in water | Min 10 mg/ml |
| Melting point | 108-110 deg C |
| Melting point/ Freezing point [°C] | 106 - 108 °C |
How N-ACETYL-L-CYSTEINE works ？
1. Powerful Antioxidant: Glutathione (GSH) precursor
After NAC enters the cell → acetyl groups are removed → L-cysteine is generated
→ directly synthesizes glutathione GSH
→ The most important endogenous antioxidant system in the cell
Functions:
• Remove free radicals
• Protect mitochondria, DNA, and cell membranes
• Reduce inflammation and oxidative stress
2. Mucus Dissolution (Cough Suppressant)
The sulfhydryl group (SH) in the molecule can break the disulfide bonds of sputum glycoproteins
→ Significantly reduces the viscosity of sputum
→ Thick sputum becomes thinner and easier to cough up
3. Liver Detoxification
It is the official antidote for acetaminophen (paracetamol) poisoning.
By increasing GSH, it combines and eliminates toxic metabolites, protecting liver cells.
4. Regulating Immunity and Inflammation
• Inhibit the NF κB inflammatory pathway
• Reduce pro-inflammatory factors
• Enhance the function of immune cells
5. Can cross the blood-brain barrier
It participates in the regulation of neurotransmitters (glutamate, dopamine), which is of great significance for brain health.
Product Applications of N-ACETYL-L-CYSTEINE
1、 Clinical Application in Medicine (Most Core and Mature)
1.Respiratory System Diseses
Acute and chronic bronchitis, pneumonia, chronic obstructive pulmonary disease (COPD)
Break down disulfide bonds in sputum proteins to reduce sputum viscosity, making thick sputum easier to cough up.
Bronchial ilation, tuberculosis, silicosis
Improve difficulty in expectoration and reduce airway obstruction.
Viral lung infections such as COVID-19 and influenza
Reduce oxidative stress and inflammatory storm in the lungs, assist in improving oxygenation.
Otolaryngology
Used for mucus dissolution in sinusitis and pharyngitis, assisting in pus discharge.
2. Liver Protection and Detoxification
Acetaminophen (Paracetamol) poisoning
Internationally recognized as the first choice for antidote, supplementing glutathione to neutralize toxic metabolites and prevent liver necrosis.
Alcoholic liver injury, drug-induced liver injury
Reduce liver cell oxidative stress and promote liver cell repair.
Non-alcoholic fatty liver disease (NAFLD)
Improve lipid metabolism and reduce liver inflammation.
3. Mental and Nervous System
Obsessive-Compulsive Disorder (OCD)
Regulate the glutamate system in the brain, widely used as an auxiliary treatment in clinical practice.
Depression, bipolar disorder, schizophrenia
Improve neuroinflammation and oxidative stress, stabilize emotions.
Parkinson’s, Alzheimer’s disease
Antioxidation, protecting dopaminergic neurons, delaying neurodegeneration.
Addiction withdrawal (nicotine, cocaine, etc.)
Reduce withdrawal reactions and craving.
4. Cardiovascular and Metabolic
Improve vascular endothelial function
Reduce the risk of atherosclerosis
Assist in lowering blood pressure
Improve insulin resistance
5. Ophthalmology
Keratitis, conjunctivitis
Dry eye syndrome (promoting mucus secretion)
Cataract assistance (antioxidant protection for the lens)
6. Dermatology
Acne (oil control, anti-inflammatory, dissolving sebaceous plugs)
Melasma, pigmentation (inhibiting melanin)
Allergic dermatitis, eczema
2、 Application of Health Supplements & Dietary Supplements (Global Mainstream)
1.Powerful Antioxidation and Anti-Aging
Increase the level of **glutathione (GSH)** in the body
Eliminate free radicals, anti-fatigue, and delay cell aging
Basic antioxidant for people who stay up late for a long time and have high stress
2. Daily Lung Protection and Sputum Removal
People who smoke, in polluted environments, and in dusty environments
Repeated coughing, excessive sputum, throat discomfort
3. Liver Care
Detoxification and alcohol protection
People who take long-term medication, stay up late, and have fatty liver
4. Skin Whitening & Brightening Inhibit melanin production
Brighten skin tone, improve dullness, and reduce pigmentation
Core ingredients of oral whitening products
5. Sports nutrition
Reduce post-exercise oxidative stress
Accelerate muscle recovery
Enhance endurance
6. Immune support
Enhance antiviral ability
Reduce the frequency and severity of colds
3、 Application in Cosmetics & Skincare
1.Whitening and fading spots
Inhibit tyrosinase, reduce melanin
Improve acne marks, pigmentation, and uneven skin tone
2. Oil control and acne removal
Regulate sebum secretion
Dissolve keratin plugs, unclog pores
Anti-inflammatory and soothing
3. Anti-aging and repair
Antioxidant, anti-light aging
Enhance skin barrier
Improve roughness and fine lines
4、 Application in Food & Functional Foods
Used in functional beverages, oral liquids, tablets, powders
Antioxidant food additives
Liver-protecting, throat-soothing, lung-moisturizing functional food raw materials
5、Application in Animal Nutrition / Feed Additives
1.Poultry farming (chickens, ducks, pigs, cows)
Enhance immunity, reduce the incidence of respiratory diseases
Antistress (high temperature, group transfer, transportation)
Improve growth performance, increase survival rate
Protect liver, reduce damage from mycotoxins
2. Aquaculture
Enhance stress resistance
Increase survival rate
Improve meat quality
6、Industrial and Other Applications
Biochemical reagents (antioxidants for cell culture)
Pharmaceutical raw materials, intermediates
Hair care products (antioxidant, strong hair strands)
Summary: The four core application tracks of NAC
Medicine: expectorant, detoxification, liver protection, neuro-psychological assistance
Health supplements: antioxidant, lung protection, whitening, liver protection
Cosmetics: whitening, acne removal, anti-aging
Feed: stress resistance, enhance immunity, promote growth
The Safety and Side Effects of N-acetyl-L-cysteine
I. Overall Safety Evaluation
NAC is a product included in the WHO Essential Medicines List and has been used in clinical practice globally for over 60 years.
It is widely used as a medicine, health supplement, and food raw material, and has extremely high overall safety.
Under normal doses, the majority of people tolerate it well.
II. Toxicological Data (Comprehensive and Authoritative Version) Acute toxicity
Oral LD₅₀ for rats: > 5000 mg/kg
→ This falls under the category of practically non-toxic.
Acute and chronic toxicity
Continuous administration showed no significant organ toxicity.
No carcinogenicity, teratogenicity, or mutagenicity (no tri-agent toxicity). Genotoxicity
The Ames test and the chromosome aberration test were both negative. Reproductive toxicity
There is no obvious embryotoxicity or teratogenicity.
Pregnant women and those in lactation period should use it under the guidance of a doctor.
III. Detailed description of side effects (adverse reactions)
1. Common side effects (low incidence, mild, transient)
1) Gastrointestinal reactions
Nausea, stomach discomfort, abdominal distension, mild diarrhea, decreased appetite
Appearing mostly in fasting and high-dose situations
Taking with meals can significantly alleviate
2) Oral and respiratory tract
Oral odor (sulfur smell, garlic smell)
Dry throat, mild choking cough
Occasional bronchial irritation during aerosol inhalation
3) Skin reactions
Mild itching, rash
Generally does not affect continued use
2. Rare side effects
Mild headache, dizziness
Fever, fatigue
Short-term blood pressure drop
Eyelid edema, conjunctivitis
3. Rare / severe side effects (rare cases reported)
Severe allergic reactions: urticaria, vasomotor urticaria, bronchospasm
Severe skin reactions: Stevens-Johnson syndrome (extremely rare)
Increased bleeding tendency: inhibition of platelet aggregation (extremely slight)
Transient elevation of liver function (cases in high-dose and long-term use)
IV.Who is not allowed to use？
Those allergic to N-acetyl-L-cysteine or any component in the formula
Those with active bronchial asthma in the acute stage (use with caution / prohibited)
V. Cautionary population (Requires doctor / professional guidance)
Active stage of gastric ulcer， duodenal ulcer
Those with bleeding tendency， taking anticoagulant drugs (warfarin， aspirin， etc.)
Asthma patients (may induce spasm)
Patients with liver dysfunction， severe liver disease
Severely impaired renal function
Pregnant women， lactating women
Children (dose should be adjusted according to age and weight)
Why choose Chempora N-ACETYL-L-CYSTEINE ?
Choosing Chempora N-ACETYL-L-CYSTEINE offers several advantages:
Premium Quality: High purity, consistent quality, and rich in proteins, fats, and essential vitamins.
Nutritional Benefits: Provides excellent emulsification, improving texture in sauces, baked goods, and more.
Versatility: Ideal for food & beverage, animal feed, and cosmetics.
Convenience: Long shelf life, easy to handle and store.
Certifications: Halal, Kosher, and ISO certified for global market compliance.
Reliable Supply: Efficient, global supply chain and sustainable sourcing.
Technical Support: Expert team available for formulation advice and customization.
Choose Chempora N-ACETYL-L-CYSTEINE for a reliable, high quality, and cost-effective solution.If you want to know more details about Sorbitol, please contact us or leave us a message.
Contact Us
CHEMPORA CO., LIMITED
Contact Person: Mr. Stephen Dean
Tel: 0086-21-5893 0128
WhatsApp & Wechat: +86 150 2666 5594
E-mail: info@chempora.com
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